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Дело в том, что для производства сперматозоидов или яйцеклеток хромосома, полученная от матери, должна соединиться с соответствующей отцовской. Чтобы объединение прошло успешно, ДНК обеих хромосом должны достаточно полно совпадать по всей длине. Если хромосомы слишком различаются, содержат много несовпадающих блоков ДНК, они не смогут слиться, полноценные сперматозоиды или яйцеклетки не образуются, и особь останется бесплодной. M. A. Jobling et al., Human Evolutionary Genetics, Garland, 2004, p. 434.